In vivo and in vitro prospection of the anti-ophidic properties exercised by the extracts of Jacaranda decurrens L.

The research and development of alternative treatments for snakebites (e.g., medicinal plants) is necessary due to the high costs existing ones. effects aqueous extracts from Jacaranda decurrens leaves, roots, xylopodium were analyzed upon venom-induced (Bothrops spp. Crotalus spp.) systemic local toxicity. able partially inhibit phospholipase activity venoms Bothrops jararacussu durissus terrificus. myotoxic, edema-inducing, coagulant, hemorrhagic activities also inhibited. SDS-PAGE showed that venom proteins intact after their incubation with extracts. This suggests possible mechanism inhibition not related degradation protein but rather binding specific sites enzymes. significantly prolonged survival time animals in lethality assay performed terrificus its toxin (crotoxin). anti-ophidic plants may aid management distant locations by reducing victim’s heal.